Patients and Families

Our Targets

KB103 for Dystrophic Epidermolysis Bullosa

KB103 is Krystal’'s patented lead product candidate that seeks to use gene therapy to treat all forms of dystrophic epidermolysis bullosa, or DEB. KB103 uses Krystal’s STAR-D technology to deliver functional human COL7A1 genes directly to the skin of affected patients. The COL7A1 genes then express functional collagen VII to form anchoring fibrils, thus stabilizing the patient’s otherwise fragile skin. The therapy is applied topically to DEB wounds. Learn more about DEB here.

KB103's Mechanism of Interraction

KB104 for Netherton Syndrome

Krystal is also developing a new product candidate, KB104, for the treatment of Netherton Syndrome (NS). KB104, also based on our underlying STAR-D technology, is engineered to deliver functional SPINK5 directly to the skin of patients that harbor mutations in this gene. Learn more about NS here.

KB105 for TGM1-deficient ARCI

Krystal is also developing a gene therapy called KB105 for the treatment of TGM1-Deficient Autosomal Recessive Congenital Ichthyosis (ARCI). KB105 uses the STAR-D technology to deliver functional TGM1 genes directly to the skin in order to express the transgultaminase-1 enzyme therein. Learn more about TGM1-Deficient ARCI here.

KB107 for Junctional Epidermolysis Bullosa

Krystal’s product candidate KB107 is being developed for the treatment of Junctional Epidermolysis Bullosa (JEB). KB107 employs our proprietary STAR-D technology to deliver wild-type LAMB3 genes directly to the skin to express the Laminin-332 subunit LamB3. Learn more about JEB here. Learn more about JEB here.

Additional Dermatological Indications

In parallel to our work on KB103, KB105, and KB107 (directed to the severe, debilitating skin diseases described above), we are actively applying our STAR-D technology to develop novel therapeutics to treat additional dermatological indications, including both aesthetic skin conditions (e.g., wrinkles) and chronic skin diseases (e.g., chronic wounds and atopic dermatitis). Learn more about aesthetic skin conditions here. Learn more about chronic skin diseases here.